![]() ![]() Discrepancies were resolved by mutual consent obtained from the third author. The first two authors individually screened published articles based on inclusion and exclusion criteria using Covidence. We have included studies (case reports, case series, cohort, and case-control studies) from the onset of the COVID-19 pandemic from December 31, 2019, up until May 4, 2021.Īll the stages of data extraction were done according to the PRISMA guideline. Thus, to fully evaluate the available data, we sought to perform this systematic review and meta-analysis. Risk factors, pathophysiology, and clinical implications of barotrauma in patients with COVID-19 are not well understood. Barotrauma has been reported among COVID-19 patients requiring invasive mechanical ventilation (IMV), non-invasive positive pressure ventilation (NIPPV), and other forms of respiratory support ranging from supplemental oxygenation by nasal cannula to heated high flow nasal cannula, , ]. Some studies have correlated COVID-19 related barotrauma with a longer length of hospitalization, longer ICU stay, and higher mortality. An increasing number of barotrauma cases have been reported with COVID-19 pneumonia in hospitalized patients. Pulmonary barotrauma refers to the spontaneous rupture of alveoli and the subsequent release or dissection of air into the various extra alveolar spaces resulting in pneumothorax, pneumomediastinum, pulmonary interstitial emphysema, pneumatocele or air cyst formation, subcutaneous emphysema, pneumopericardium, and or pneumoperitoneum. ![]()
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